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  1. 25 Oct 2022 Journal Article Cell Reports

    tRNA methylation resolves codon usage bias at the limit of cell viability

    Isao Masuda, Yuka Yamaki, Rajesh Detroja, Somnath Tagore, Henry Moore, Sunita Maharjan, Yuko Nakano, Thomas Christian, Ryuma Matsubara, Todd M Lowe, Milana Frenkel-Morgenstern, Ya-Ming Hou
    Abstract

    Codon usage of each genome is closely correlated with the abundance of tRNA isoacceptors. How codon usage bias is resolved by tRNA post-transcriptional modifications is largely unknown. Here we demonstrate that the N1-methylation of guanosine at position 37 (m1G37) on the 3′-side of the anticodon, while not directly responsible for reading of codons, is a neutralizer

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  2. 19 Oct 2022 Journal Article Future Foods

    Responses of the human gut microbiota to physiologically digested insect powders or isolated chitin thereof

    Gil Refael, Hila Tarazi Riess, Carmit Shani Levi, Faiga Magzal, Snait Tamir, Omry Koren, Uri Lesmes
    Abstract

    As part of the quest for sustainable food choices, edible insects draw increasing attention. Nevertheless, not enough is known regarding their digestive fate and specifically little is known on the colonic fermentability of edible insects or chitin, which is found in many insects or crustaceans. This study interrogated the properties and fermentability of powders from

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  3. 18 Oct 2022 Journal Article Frontiers in Molecular Biosciences

    It’s all in the numbers: Cohesin stoichiometry

    Abstract

    Cohesin, a structural maintenance of chromosome (SMC) complex, organizes chromatin into three-dimensional structures by threading chromatin into loops and stabilizing long-range chromatin interactions. Four subunits in a 1:1:1:1 ratio compose the cohesin core, which is regulated by auxiliary factors that interact with or modify the core subunits. An ongoing debate about

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  4. 17 Oct 2022 Journal Article Scientific Reports

    Fold-change of chromatin condensation in yeast is a conserved property

    Katreena Yamin, Swati Bijlani, Judith Berman, Awakash Soni, Joseph Shlomai, Bijoy Mukut Buragohain, Michal Werbner, Meital Gal-Tanamy, Avi Matityahu, Itay Onn
    Abstract

    During mitosis, chromatin is condensed and organized into mitotic chromosomes. Condensation is critical for genome stability and dynamics, yet the degree of condensation is significantly different between multicellular and single-cell eukaryotes. What is less clear is whether there is a minimum degree of chromosome condensation in unicellular eukaryotes. Here, we

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  5. 10 Oct 2022 Preprint medRxiv

    Associations Between Reported Post-COVID-19 Symptoms and Subjective Well-Being, Israel, July 2021 -April 2022

    Abstract

    Objective

    We describe a case of persisting readings from a fingertip pulse oximeter (FPO) in an elderly cachectic woman with pancreatic cancer, who fulfilled all classical criteria of death.

    Methods

    It is an instructive example of a home hospice patient who died during the physician’s intervention. Although all classical signs of death had been confirmed several times

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  6. 6 Oct 2022 Journal Article Vaccine

    Equity of the Meningitis B vaccination programme in England, 2016–2018

    Karen S Tiley, Joanne White, Nick Andrews, Elise Tessier, Michael Edelstein
    Abstract

    In England, the Meningitis B (MenB) vaccine is scheduled at eight and 16 weeks with a booster dose at one year of age and protects children against invasive bacterial meningococcal disease caused by Neisseria meningitidis serogroup B. Coverage of the second dose of MenB vaccine at 12 months was >92% in 2017/18, but this may mask inequalities in coverage

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  7. 6 Oct 2022 Journal Article Developing World Bioethics

    Reasons for and insights about HPV vaccination refusal among ultra-Orthodox Jewish mothers

    Rivka Zach, Miriam Ethel Bentwich
    Abstract

    Background

    Vaccination against human papillomavirus (HPV) is a pivotal tool for preventing a significant cause of cervical cancer. One particular culturally recognized context associated with negative attitudes toward the HPV vaccine is the religiousness of parents. However, relatively speaking, there remains a scarcity of studies that have focused specifically on

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  8. 5 Oct 2022 Journal Article International Journal of Impotence Research

    Opportunities and challenges with the German act for the protection of children with variations of sex development

    Limor Meoded Danon, Katinka Schweizer, B Thies
    Abstract

    In May 2021, the German parliament passed a long-debated law to protect children with variations of sex development/sex characteristics from medically unnecessary surgeries until they are old enough to decide for themselves. This law joins similar laws passed in other countries in recent years and recognizes the rights of people with variations of sex development to

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  9. 5 Oct 2022 Journal Article Environmental Research

    Residence near industrial complex and cancer incidence: A registry-based cohort of 1,022,637 participants with a follow-up of 21 years, Israel

    Abstract

    Background

    Industrial complex (IC) residence is associated with higher cancer incidence in adults and children. However, the effect on young adults and the residence duration are not well described. Since the beginning of the 20th century, the Haifa bay area (HBA) has a major IC area with petrochemical industry complex and many other industries. The objectives of the

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  10. 4 Oct 2022 Journal Article BMC Medicine

    Both indirect maternal and direct fetal genetic effects reflect the observational relationship between higher birth weight and lower adult bone mass

    Jiang-Wei Xia, Lin Zhang, Jin Li, Cheng-Da Yuan, Xiao-Wei Zhu, Yu Qian, Saber Khederzadeh, Jia-Xuan Gu, Lin Xu, Jian-Hua Gao, Ke-Qi Liu, David Karasik, ... show all 15 authors
    Abstract

    Background

    Birth weight is considered not only to undermine future growth, but also to induce lifelong diseases; the aim of this study is to explore the relationship between birth weight and adult bone mass.

    Methods

    We performed multivariable regression analyses to assess the association of birth weight with bone parameters measured by dual-energy X-ray absorptiometry

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