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  1. 22 Sep 2023 Journal Article Scientific Reports

    Association between BNT162b2 vaccination and health-related quality of life up to 18 months post-SARS-CoV-2 infection in Israel

    Abstract

    We determined whether COVID-19 vaccination was associated with Quality of Life (QoL) changes among individuals previously infected with SARS-CoV-2 in Israel. Using a validated questionnaire, we collected information about socio-demographics, SARS-CoV-2 infection, COVID-19 vaccination and QoL (using the EQ-5D-5L tool) 3–18 months post-infection among adults tested

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  2. 21 Sep 2023 Journal Article Nanoscale

    A single filament biomechanical study of the enteropathogenic Escherichia coli Type III secretion system reveals a high elastic aspect ratio

    Moran Elias-Mordechai, Nofar David, Sonia Oren, Maya Georgia Pelah, Jürgen Jopp, Boris Fichtman, Amnon Harel, Ronen Berkovich, Neta Sal-Man
    Abstract

    Type III secretion systems (T3SSs) are syringe-like protein complexes used by some of the most harmful bacterial pathogens to infect host cells. While the T3SS filament, a long hollow conduit that bridges between bacteria and host cells, has been characterized structurally, very little is known about its physical properties. These filaments should endure shear and normal

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  3. 19 Sep 2023 Journal Article Experimental Dermatology

    Nano-encapsulated anandamide reduces inflammatory cytokines in vitro and lesion severity in a murine model of cutaneous lupus erythematosus

    Erika T McCormick, Draganski Andrew, Samantha A Chalmers, Joseph Zahn, Sayra J Garcia, Dillon Nussbaum, Friedman Adam, Chaim Putterman, Friedman Joel
    Abstract

    Cutaneous lupus erythematosus (CLE) is a heterogeneous autoimmune skin disease which occurs independently and in conjunction with systemic lupus erythematosus. Drug development for CLE is severely lacking. Anandamide (AEA) is a primary endocannabinoid which exhibits immunomodulatory effects through mixed cannabinoid receptor agonism. We evaluated AEA as topical treatment

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  4. 8 Sep 2023 Preprint Research Square

    New insights into canine milk: a multi-omics approach

    Abstract

    Background A mother’s milk is considered the gold standard of nutrition in neonates and is a source of cytokines, immunoglobulins, growth factors, and other important components, yet little is known about the components of canine milk, specifically colostrum, and the knowledge related to its microbial and metabolic profiles is particularly underwhelming. In this study

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  5. 4 Sep 2023 Preprint Preprints

    The Potential Use of Peptides in the Fight against Chagas Disease and Leishmaniasis

    Abstract

    Parasitic diseases are among the most serious public health problems in developing countries, causing high mortality and economic burdens. The Trypanosomatidae family includes Leishmania spp. and Trypanosoma cruzi, which cause leishmaniasis and Chagas disease, respectively. Both these parasites are among the major agents of neglected tropical diseases (NTDs). Leishmaniasis

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  6. 3 Sep 2023 Preprint PsyArXiv

    Expectation-Updating: Understanding the Dynamics of Expectancy in Psychotherapy for Depression

    Liron Rozenkrantz, Oleksandr Laskorunskiy, Sigal Zilcha-Mano, Itai Dattner
    Abstract

    Background: In psychotherapy, patients’ expectations from treatment, i.e., expectancy, are associated with treatment success. The current study introduces the concept of expectancy updating, the dynamics of expectancy during the psychotherapeutic process. Examining how expectancy develops and changes throughout treatment, and whether its development is informative of

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  7. Sep 2023 Journal Article Journal of Biological Chemistry

    A conserved arginine within the αC-helix of Erk1/2 is a latch of autoactivation and of oncogenic capabilities

    Nadine Soudah, Alexey Baskin, Karin Smorodinsky-Atias, Jonah Beenstock, Yifat Ganon, Ruchama Hayouka, Mohammed Aboraya, Oded Livnah, Ronit Ilouz, David Engelberg
    Abstract

    Eukaryotic protein kinases (EPKs) adopt an active conformation following phosphorylation of a particular activation loop residue. Most EPKs spontaneously autophosphorylate this residue. While structure-function relationships of the active conformation are essentially understood, those of the ‘prone-to-autophosphorylate’ conformation are unclear. Here, we propose that

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  8. 28 Aug 2023 Journal Article The Lancet

    Long COVID in low-income and middle-income countries: the hidden public health crisis

    Waasila Jassat, Luis Felipe Reyes, Daniel Munblit, Janice Caoili, Fernando Bozza, Madiha Hashmi, Michael Edelstein, Cheryl Cohen, Carlos A Alvarez-Moreno, Bin Cao
    Abstract

    The COVID-19 pandemic exposed crucial fault lines in society both within and between different societies. Over the past 3 years, inequity has been highlighted in several areas including research capacity, surveillance, and availability of COVID-19 therapeutics and vaccines. These disparities are particularly pronounced when comparing high-income countries (HICs) and

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  9. 23 Aug 2023 Journal Article GeroScience

    Signs of aging in midlife: physical function and sex differences in microbiota

    Roy Tzemah-Shahar, Sondra Turjeman, Efrat Sharon, Gila Gamliel, Hagit Hochner, Omry Koren, Maayan Agmon
    Abstract

    Microbiota composition has been linked to physical activity, health measures, and biological age, but a shared profile has yet to be shown. The aim of this study was to examine the associations between microbiota composition and measures of function, such as a composite measure of physical capacity, and biological age in midlife, prior to onset of age-related diseases

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  10. 16 Aug 2023 Journal Article Political Psychology

    How people update their beliefs about climate change: An experimental investigation of the optimistic update bias and how to reduce it

    Tobias Kube, Marlis Wullenkord, Liron Rozenkrantz, Peter Kramer, Sophia Lieb, Claudia Menzel
    Abstract

    People usually update their beliefs selectively in response to good news and disregard bad news. Here, we investigated in two preregistered experiments (N = 278 and N = 306) (1) whether such valence-dependent belief updating also underlies information processing in the context of climate change and (2) whether it can be altered by interventions informing about different

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