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  1. 4 Mar 2023 Journal Article Current Osteoporosis Reports

    Proceedings of the Post-Genome Analysis for Musculoskeletal Biology Workshop

    Cheryl L Ackert-Bicknell, David Karasik
    Abstract

    Purpose of the Review

    Herein, we report on the proceedings of the workshop entitled “Post-Genome analysis for musculoskeletal biology” that was held in July of 2022 in Safed, Galilee, Israel. Supported by the Israel Science Foundation, the goal of this workshop was to bring together established investigators and their trainees who were interested in understanding the

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  2. 27 Feb 2023 Journal Article Nature Human Behaviour

    A highly replicable decline in mood during rest and simple tasks

    David C Jangraw, Hanna Keren, Haorui Sun, Rachel L Bedder, Robb B Rutledge, Francisco C Pereira, Adam G Thomas, Daniel S Pine, Charles Y Zheng, Dylan M Nielson, Argyris Stringaris
    Abstract

    Does our mood change as time passes? This question is central to behavioural and affective science, yet it remains largely unexamined. To investigate, we intermixed subjective momentary mood ratings into repetitive psychology paradigms. Here we demonstrate that task and rest periods lowered participants’ mood, an effect we call ‘Mood Drift Over Time’. This finding was

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  3. 16 Feb 2023 Journal Article Tropical Medicine and Infectious Disease

    Latent Tuberculosis Treatment among Hard-to-Reach Ethiopian Immigrants: Nurse-Managed Directly Observed versus Self-Administered Isoniazid Therapy

    Hashem Bishara, Manfred Green, Amer Saffouri, Daniel Weiler-Ravell
    Abstract

    Background: The treatment of latent tuberculosis infection (LTBI) among high-risk populations is an essential component of Tuberculosis (TB) elimination. However, non-compliance with LTBI treatment remains a major obstacle hindering TB elimination efforts. We have previously reported high treatment compliance with nurse-managed, twice-weekly, directly observed Isoniazid

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  4. 15 Feb 2023 Preprint Social Science Research Network

    The Effect of Random Assigned Exposure to Green Walls Compared to Gray Walls on State Positive Body Image and Mediation by Feelings

    Reem Mohsen, Diana Saadi, Itamar M Lensky, Keren Agay-Shay
    Abstract

    Background Exposure to natural environments has beneficial effects on health and mental well-being. Less is known about the effects of exposure to green walls (GW) and the effects on state positive body image (SPBI). Our aim was to examine the effect of short visit to GW compared to gray walls on SPBI and to examine possible mediation pathways through feelings. Methods

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  5. 15 Feb 2023 Journal Article Breastfeeding Medicine

    The Risk of Breakthrough Bleeding Justifies the Use of Combined Hormonal Contraception Over Progesterone-Only Pills While Breastfeeding

    Lior Segev, Abraham O Samson, Goldie Katz-Samson, Naama Srebnik
    Abstract

    Breakthrough bleeding is a side effect of progesterone-only pills (POPs) in 40% of women, and is reduced to 10% with combined hormonal contraceptives (CHCs). In addition, breakthrough bleeding is reduced if POP is supplemented with norethisterone. As breakthrough bleeding is responsible for a quarter of women stopping the pill, it is vital to realize that CHC is an

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  6. 7 Feb 2023 Conference Paper Cells, Cells and Nothing but Cells: Discoveries, Challenges and Directions

    Molecular genetics for probiotic engineering: How fermentatable sugars affect aggregation, adhesion and agression in Lactobacillaceae

    Ronit Suissa, Michael M Meijler, Omry Koren, Ilana Kolodkin-Gal
    Abstract

    Lactobacillaceae are Gram-positive, and lactic acid-positive (LAB) bacteria frequently serve as probiotics. We first systematically compared five LAB strains for the effects of different carbohydrates on their free-living and biofilm lifestyles. We found that fermentable sugars triggered an altered carrying capacity with strain specificity during planktonic growth

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  7. 4 Feb 2023 Journal Article Viruses

    The Landscape of Expressed Chimeric Transcripts in the Blood of Severe COVID-19 Infected Patients

    Abstract

    The ongoing COVID-19 pandemic caused by SARS-CoV-2 infections has quickly developed into a global public health threat. COVID-19 patients show distinct clinical features, and in some cases, during the severe stage of the condition, the disease severity leads to an acute respiratory disorder. In spite of several pieces of research in this area, the molecular mechanisms

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  8. 3 Feb 2023 Journal Article Neuropharmacology

    Gut microbes and host behavior: The forgotten members of the gut-microbiome

    Abstract

    The gut microbiota refers to an entire population of microorganisms that colonize the gut. This community includes viruses, prokaryotes (bacteria and archaea), and eukaryotes (fungi and parasites). Multiple studies in the last decades described the significant involvement of gut bacteria in gut-brain axis communication; however, the involvement of other members of the

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  9. 3 Feb 2023 Journal Article Cell Host & Microbe

    Autophagy controls mucus secretion from intestinal goblet cells by alleviating ER stress

    Abstract

    Colonic goblet cells are specialized epithelial cells that secrete mucus to physically separate the host and its microbiota, thus preventing bacterial invasion and inflammation. How goblet cells control the amount of mucus they secrete is unclear. We found that constitutive activation of autophagy in mice via Beclin 1 enables the production of a thicker and less penetrable

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  10. 1 Feb 2023 Journal Article International Journal of Medical Informatics

    Monitoring the COVID-19 immunisation programme through a national immunisation Management system – England’s experience

    Elise Tessier, Michael Edelstein, Camille Tsang, Freja Kirsebom, Charlotte Gower, Colin N J Campbell, Mary Ramsay, Joanne White, Nick Andrews, Jamie Lopez Bernal, Julia Stowe
    Abstract

    Background

    In England routine vaccinations are recorded in either the patients General Practice record or in series of sub-national vaccine registers that are not interoperable. During the COVID-19 pandemic it was established that COVID vaccines would need to be delivered in multiple settings where current vaccine registers do not exist. We describe how a national

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