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  1. 10 Feb 2024 Journal Article Microbiome

    Gut microbiome-metabolome interactions predict host condition

    Oshrit Shtossel, Omry Koren, Iris Shai, Ehud Rinott, Yoram Louzoun
    Abstract

    The effect of microbes on their human host is often mediated through changes in metabolite concentrations. As such, multiple tools have been proposed to predict metabolite concentrations from microbial taxa frequencies. Such tools typically fail to capture the dependence of the microbiome-metabolite relation on the environment. We propose to treat the microbiome-metabolome

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  2. 9 Feb 2024 Journal Article Brain Communications

    Sex differences in post-acute neurological sequelae of SARS-CoV-2 and symptom resolution in adults after COVID-19 hospitalization: an international multicenter prospective observational study

    Sung-Min Cho, Lavienraj Premraj, Denise Battaglini, JP Fanning, J Suen, GL Bassi, J Fraser, Chiara Robba, M Griffee, T Solomon, Malcolm G Semple, J Kenneth Baillie, ... show all 50 authors
    Abstract

    Although it is known that COVID-19 can present with a range of neurological manifestations and in-hospital complications, sparse data exist if these initial neurological symptoms of COVID-19 are closely associated with post-acute neurological sequelae of SARS-CoV-2 (PANSC) and if female versus male sex impacts the symptom resolution. In this international, multicentre

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  3. 7 Feb 2024 Journal Article British Journal of Dermatology

    487 - Adult atopic dermatitis is associated with impaired oral health and oral dysbiosis - a case-control study

    Aaya Shahin, Yael A Leshem, Yossi Taieb, Sharon Baum, Aviv Barzilai, Danielle Jedda, Efrat Sharon, Omry Koren, Shunit Coppenhagen-Glazer, Ronen Hazan, Yael Houri-Haddad, Shoshana Greenberger
    Abstract

    Previous studies linked chronic oral diseases to skin disorders such as psoriasis. However, data about oral health and oral microbiota in atopic dermatitis (AD) is sparse.

    To compare the oral health status and oral microbiota of AD patients and healthy controls.

    This was a prospective sex and age- matched case-control study comparing adult participants with and without

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  4. 5 Feb 2024 Journal Article Cancer Research Communications

    Antibody-drug conjugate αEGFR-E-P125A reduces triple-negative breast cancer vasculogenic mimicry, motility, and metastasis through inhibition of EGFR, integrin, and FAK/STAT3 signaling

    Ankita P Sankar, Hyun-Mi Cho, Seung Uon Shin, Tal Sneh, Sundaram Ramakrishnan, Christian Elledge, Yu Zhang, Rathin Das, Hava Gil-Henn, Joseph D Rosenblatt
    Abstract

    Abstract. Primary tumor growth and metastasis in triple-negative breast cancer (TNBC) require supporting vasculature, which develop through a combination of endothelial angiogenesis and vasculogenic mimicry (VM), a process associated with aggressive metastatic behavior in which vascular-like structures are lined by tumor cells. We developed αEGFR-E-P125A, an

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  5. 4 Feb 2024 Journal Article Pharmaceutics

    The Potential Use of Peptides in the Fight against Chagas Disease and Leishmaniasis

    Abstract

    Chagas disease and leishmaniasis are both neglected tropical diseases that affect millions of people around the world. Leishmaniasis is currently the second most widespread vector-borne parasitic disease after malaria. The World Health Organization records approximately 0.7–1 million newly diagnosed leishmaniasis cases each year, resulting in approximately 20,000–30,000

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  6. 3 Feb 2024 Journal Article Food Hydrocolloids

    Digestive fate of milk and egg-derived amyloids: Attenuated digestive proteolysis and impact on the trajectory of the gut microbiota

    Gil Refael, Yizhaq Engelberg, Alon Romano, Gabriela Amiram, Eilon Barnea, Carmit Shani Levi, Sondra Turjeman, Meytal Landau, Omry Koren, Uri Lesmes
    Abstract

    In an era in which protein consumption is enthusiastically advocated, this work explored the possible formation of proteinaceous amyloids in foods and their unchartered digestive fate. Evidence herein corroborates processing induces formation of amyloid-like architectures from β-lactoglobulin or ovalbumin. Such supramolecular assemblies exhibit attenuated susceptibility

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  7. 2 Feb 2024 Journal Article Science of The Total Environment

    Residential greenness and lower breast and prostate cancer incidence: Evidence from a retrospective cohort study of 977,644 participants from Israel

    Abstract

    Background

    There is limited evidence on the associations between residential greenness and cancer incidence in longitudinal studies.

    Objectives

    The aim of the study was to evaluate the associations between weighted mean residential greenness exposure and cancer incidence.

    Methods

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  8. 1 Feb 2024 Journal Article Health Policy and Technology

    Apps don't work for patients who don't use them: Towards frameworks for digital therapeutics adherence

    David G Schwartz, Sivan Spitzer, Michael Khalemsky, Arturo Heyner Cano-Bejar, Soumya Ray, Jeng-Yuan Chiou, Rizan Sakhnini, Raya Lanin, Menachem M Meir, Ming-Che Tsai
    Abstract

    Objectives

    Digital therapeutics such as mobile health applications (mHealth apps) are becoming part of patients’ treatment programs. Ensuring patients actually use (adhere to) an app as prescribed, effectively measuring and interpreting usage, and detecting clinical non-compliance are fundamental to effective treatment. Clinicians are not currently prepared to deal

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  9. 31 Jan 2024 Journal Article Frontiers in Nutrition

    Enhancing cognitive function in older adults: dietary approaches and implications

    Baruh Polis, Abraham O Samson
    Abstract

    Natural aging encompasses physiological and psychological changes that impact overall health and quality of life. Mitigating these effects requires physical and mental exercise, coupled with proper nutrition. Notably, protein malnutrition emerges as a potential risk factor for senile dementia, with insufficient intake correlating with premature cognitive decline. Adequate

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  10. 16 Jan 2024 Preprint bioRxiv

    Blood immunophenotyping identifies distinct kidney histopathology and outcomes in patients with lupus nephritis

    Chaim Putterman
    Alice Horisberger, Alec Griffith, Joshua Keegan, Arnon Arazi, John Pulford, Ekaterina Murzin, Kaitlyn Howard, Brandon Hancock, Andrea Fava, Takanori Sasaki, Tusharkanti Ghosh, Jun Inamo, ... show all 54 authors
    Abstract

    Lupus nephritis (LN) is a frequent manifestation of systemic lupus erythematosus, and fewer than half of patients achieve complete renal response with standard immunosuppressants. Identifying non-invasive, blood-based pathologic immune alterations associated with renal injury could aid therapeutic decisions. Here, we used mass cytometry immunophenotyping of peripheral

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