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2 Apr 2024 • Journal Article • Journal of Epidemiology and Global Health
Biofilm Formation by Hospital-Acquired Resistant Bacteria Isolated from Respiratory Samples
AbstractBackground
Hospital-acquired resistant infections (HARI) are infections, which develop 48 h or more after admission to a healthcare facility. HARI pose a considerably acute challenge, due to limited treatment options. These infections are associated bacterial biofilms, which act as a physical barrier to diverse external stresses, such as desiccation, antimicrobials
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31 Mar 2024 • Journal Article • Autoimmunity
Animal models of neuropsychiatric systemic lupus erythematosus: deciphering the complexity and guiding therapeutic development
AbstractSystemic lupus erythematosus (SLE) poses formidable challenges due to its multifaceted etiology while impacting multiple tissues and organs and displaying diverse clinical manifestations. Genetic and environmental factors contribute to SLE complexity, with relatively limited approved therapeutic options. Murine models offer insights into SLE pathogenesis but do not
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28 Mar 2024 • Journal Article • Trends in Endocrinology & Metabolism
A perspective on muscle phenotyping in musculoskeletal research
AbstractMusculoskeletal research should synergistically investigate bone and muscle to inform approaches for maintaining mobility and to avoid bone fractures. The relationship between sarcopenia and osteoporosis, integrated in the term ‘osteosarcopenia', is underscored by the close association shown between these two conditions in many studies, whereby one entity emerges as a
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28 Mar 2024 • Journal Article • Journal of Clinical Medicine
Proton Pump Inhibitors and Cancer Risk: A Comprehensive Review of Epidemiological and Mechanistic Evidence
AbstractBackground: Proton pump inhibitors (PPIs) are commonly prescribed long-acting drugs used to treat acid reflux, gastroesophageal reflux disease (GERD), and peptic ulcers. Recently, concerns have been raised about their safety, particularly due to the association between long-term PPI use and cancer development. Multiple comprehensive studies have consistently suggested
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26 Mar 2024 • Journal Article • Annals of the Rheumatic Diseases
Characterisation of choroid plexus-infiltrating T cells reveals novel therapeutic targets in murine neuropsychiatric lupus
AbstractObjective
Diffuse central nervous system manifestations, referred to as neuropsychiatric lupus (NPSLE), are observed in 20–40% of lupus patients and involve complex mechanisms that have not yet been adequately elucidated. In murine NPSLE models, choroid plexus (ChP)-infiltrating T cells have not been fully evaluated as drivers of neuropsychiatric disease.
Method
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26 Mar 2024 • Preprint • medRxiv
The applications of circulating cell-free DNA for oral squamous cell carcinoma patients as non-invasive diagnostics of structural variants, fusions and oncoviruses
AbstractCirculating cell-free DNA (cfDNA) has been widely used as a prognostic marker for different cancers. In this study, we used cfDNA from oral squamous cell carcinoma (OSCC) patients to study various correlation factors that could improve the disease early-stage diagnostics and/or prognosis. We found that OSCC patient cfDNA concentration can serve as an indicator of tumor
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25 Mar 2024 • Journal Article • Science of The Total Environment
Residential greenness and lower breast and prostate cancer incidence: Evidence from a retrospective cohort study of 977,644 participants from Israel
AbstractBackground
There is limited evidence on the associations between residential greenness and cancer incidence in longitudinal studies.
Objectives
The aim of the study was to evaluate the associations between weighted mean residential greenness exposure and cancer incidence.
Methods
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20 Mar 2024 • Preprint • bioRxiv
Antibiotics damage the colonic mucus barrier in a microbiota-independent manner
AbstractAntibiotic use is a risk factor for development of inflammatory bowel diseases (IBDs). IBDs are characterized by a damaged mucus layer, which does not properly separate the host intestinal epithelium from the microbiota. Here, we hypothesized that antibiotics might affect the integrity of the mucus barrier. By systematically determining the effects of different antibiotics
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20 Mar 2024 • Journal Article • Neuroscience
The Predictive Potential of Heart Rate Variability for Depression
AbstractHeart rate variability (HRV), a measure of the fluctuations in the intervals between consecutive heartbeats, is an indicator of changes in the autonomic nervous system. A chronic reduction in HRV has been repeatedly linked to clinical depression. However, the chronological and mechanistic aspects of this relationship, between the neural, physiological, and
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20 Mar 2024 • Journal Article • Cancer Research Communications
The crosstalk between intestinal microbiota and MDSCs fuels colitis associated cancer development
AbstractAbstract. Intestinal chronic inflammation is associated with microbial dysbiosis and accumulation of various immune cells including myeloid-derived suppressor cells (MDSCs), which profoundly impact the immune microenvironment, perturb homeostasis and increase the risk to develop colitis-associated colorectal cancer (CAC). However, the specific MDSCs-dysbiotic microbiota
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