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10 Jun 2024 • Preprint • Preprints.org
Advances in Modeling Approaches for Oral Drug Delivery: Artificial Intelligence, Physiologically Based Pharmacokinetic, and First-Principal Models
AbstractOral drug absorption is the primary route for drug administration. However, this process hinges on multiple factors, including the drug’s physicochemical properties, formulation characteristics, and gastrointestinal physiology. Given its intricacy and the exorbitant costs associated with experimentation, the trial-and-error method proves prohibitively expensive. Theoretical
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6 Jun 2024 • Journal Article • Future Medicinal Chemistry
CF2H: a fascinating group for application in drug development enabling modulation of many molecular properties
AbstractFluorination of lead compounds in drug discovery has long been one of the medicinal chemists' favorite strate-gies in the strive for improved new drugs from both pharmacokinetic and pharmacodynamic points of view. Fluorine, being the most electronegative atom in the periodic table affects many molecular properties such as the electron charge distribution, conformation
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23 May 2024 • Journal Article • BMC Genomic Data
Genome sequence of two novel virulent clinical strains of Burkholderia pseudomallei isolated from acute melioidosis cases imported to Israel from India and Thailand
AbstractObjective Burkholderia pseudomallei, the etiological cause of melioidosis, is a soil saprophyte endemic in South-East Asia, where it constitutes a public health concern of high-priority. Melioidosis cases are sporadically identified in nonendemic areas, usually associated with travelers or import of goods from endemic regions. Due to extensive intercontinental traveling
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21 May 2024 • Journal Article • Scientific Reports
Short-and long-term outcomes of pulmonary exposure to a sublethal dose of ricin in mice
AbstractRicin, an extremely potent toxin produced from the seeds of castor plant, Ricinus communis, is ribosome-inactivating protein that blocks cell-protein synthesis. It is considered a biological threat due to worldwide availability of castor beans, massive quantities as a by-product of castor oil production, high stability and ease of production. The consequence of exposure
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8 May 2024 • Journal Article • RSC Advances
Acetohydroxamic acid salts: mild, simple and effective degradation reagents to counter Novichok nerve agents
AbstractNovichoks is the latest known class of organophosphorus nerve agents to be developed. These highly lethal persistent agents, which exert their toxicity mainly through dermal exposure, pose new major challenges in mitigating their effect, mainly in respect to decontamination and medical countermeasures. Herein we report on the effective degradation of Novichok agents
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5 May 2024 • Preprint • ESS Open Archive
A multi-disciplinary characterization and forecast of a unique fog event: microphysics measurements, mesoscale modeling and machine learning
AbstractWe present a multidisciplinary study of the microphysics, mesoscale and synoptic conditions of a rare radiation-fog event in the central and southern regions of Israel during January 3-6, 2021. The fog developed during nighttime from south to central coastal areas and dissipated at morning. The synoptic conditions were dominated by Red Sea Troughs at the surface without
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4 May 2024 • Preprint • bioRxiv
Mathematical model of intestinal lipolysis of a long-chain triglyceride
AbstractLipids are an important component of food and oral drug formulations. Upon release into gastrointestinal fluids, triglycerides, common components of foods and drug delivery systems, form emulsions and are digested into simpler amphiphilic lipids (e.g., fatty acids) that can associate with intestinal bile micelles and impact their drug solubilization capacity. Digestion
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May 2024 • Journal Article • Surfaces and Interfaces
Introducing surface roughness in adhesion for stochastic and Rock'n'Roll models to describe particle resuspension in turbulent flows
AbstractResuspension of colloidal particles plays an important role in various environmental and industrial implications and is particularly influenced by the interactions at the particle-surface interface. Here we explore the effect of surface roughness on resuspension of colloidal particles by incorporating a phenomenological adhesion model that includes surface roughness
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1 May 2024 • Journal Article • Vaccines
Induction of Superior Systemic and Mucosal Protective Immunity to SARS-CoV-2 by Nasal Administration of a VSV–ΔG–Spike Vaccine
AbstractThe emergence of rapidly spreading variants of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) poses a major challenge to vaccines’ protective efficacy. Intramuscular (IM) vaccine administration induces short-lived immunity but does not prevent infection and transmission. New vaccination strategies are needed to extend the longevity of vaccine protection
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30 Apr 2024 • Journal Article • Antimicrobial Agents and Chemotherapy
Doxycycline, levofloxacin, and moxifloxacin are superior to ciprofloxacin in treating anthrax meningitis in rabbits and NHP
AbstractEfficient treatment of anthrax-related meningitis in patients poses a significant therapeutic challenge. Previously, we demonstrated in our anthrax meningitis rabbit model that ciprofloxacin treatment is ineffective with most of the treated animals succumbing to the infection. Herein we tested the efficacy of doxycycline in our rabbit model and found it highly effective
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