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10 Jan 2025 • Journal Article • Environments
Adaptive Degenerate Space-Based Method for Pollutant Source Term Estimation Using a Backward Lagrangian Stochastic Model
AbstractA major challenge in accidental or unregulated releases is the ability to identify the pollutant source, especially if the location is in a large industrial area. Usually in such cases, only a few sensors provide non-zero signal. A crucial issue is therefore the ability to use a small number of sensors in order to identify the source location and rate of emission. The
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23 Dec 2024 • Preprint • Preprints
Purification of an FC-Fusion Protein with [Bathophenathroline: metal] Complexes
AbstractIn this study, we aim at assessing an alternative method for purification of Fc-fusion proteins that does not rely on chromatographic media or ligands. Recombinant human acetylcholinesterase, fused to the Fc-domain of human IgG1 (henceforth, AChE-Fc), was purified with precipitated aromatic complexes composed of the bathophenanthroline (henceforth, batho) chelator with
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13 Dec 2024 • Journal Article • Science Advances
Two-in-one nanoparticle platform induces a strong therapeutic effect of targeted therapies in P-selectin–expressing cancers
AbstractCombined therapies in cancer treatment aim to enhance antitumor activity. However, delivering multiple small molecules imposes challenges, as different drugs have distinct pharmacokinetic profiles and tumor penetration abilities, affecting their therapeutic efficacy. To circumvent this, poly(lactic-co-glycolic acid) (PLGA)–polyethylene glycol (PEG)–based nanoparticles
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9 Dec 2024 • Journal Article • Organics
Simple and Selective Determination of Free Chlorine in Aqueous Solutions by an Electrophilic Aromatic Substitution Reaction Followed by Liquid Chromatography Coupled with Mass Spectrometry
AbstractWe developed a selective technique to rapidly measure free chlorine, which is the sum of elemental chlorine (Cl2), hypochlorous acid (HOCl), and hypochlorite (OCl−) in water samples via an electrophilic aromatic substitution reaction hyphenated with liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). Sample preparation involved
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Dec 2024 • Journal Article • TrAC Trends in Analytical Chemistry
Metabolite Annotation through Stable Isotope Labeling
AbstractStable isotope labeling (SIL) is a powerful tool for probing cellular metabolism and has been increasingly employed for metabolite annotation in mass spectrometry-based metabolomics. Herein, we outline the principles and methods of designing and performing SIL-based experiments in metabolomics studies. Further, we summarize different SIL approaches and highlight recent
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30 Oct 2024 • Journal Article • Rapid Communications in Mass Spectrometry
Structural elucidation of tramadol, its derivatives, and metabolites using chemical derivatization and liquid chromatography–high-resolution tandem mass spectrometry
AbstractRationale
Tramadol (T) is a strong painkiller drug that belongs to the opioid analgesic group. Several accidental intoxication cases after oral administration of T have been reported in the past decade. Tramadol, its derivatives, and metabolites present information-limited mass spectra with one prominent peak representing the amine-containing residue; therefore, their
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28 Oct 2024 • Journal Article • Pathogens
Closing the Gaps: Testing the Efficacy of Carbapenem and Cephalosporin Treatments of Late-Stage Anthrax in Rabbits
AbstractAnthrax is a fatal zoonotic disease caused by exposure to Bacillus anthracis spores. The CDC’s guidelines divide anthrax treatment into three categories according to disease progression: post-exposure prophylaxis (PEP), systemic, and systemic with a suspicion of CNS infection. While the prognosis for PEP or the early treatment of systemic anthrax is very good, ingress
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25 Oct 2024 • Preprint • Social Science Research Network
Links between the Indian Ocean Dipole and Persistent Dry Spells in the Eastern Mediterranean Winter
AbstractPersistent Dry Spells (PDS) during winter in the eastern Mediterranean are crucial to understanding the regional challenges of water resources and mitigating agricultural and economic impacts. Winter dry spells significantly affect ecosystem stability, public health, and socioeconomic conditions in a region susceptible to climate variability. Therefore, extending the
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22 Oct 2024 • Journal Article • The American Journal of Tropical Medicine and Hygiene
Case Report: A Novel Virulent Clinical Isolate of Burkholderia pseudomallei Imported from Thailand Exhibiting Resistance to Trimethoprim-Sulfamethoxazole
AbstractWe present the investigation of a Burkholderia pseudomallei strain isolated from the urine of a 56-year-old male returning from a recreational trip to Thailand. The patient initially presented with fever and chills, and lobar as well as bladder and prostate involvement was demonstrated on imaging. Treatment first involved trimethoprim-sulfamethoxazole, the backbone of
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10 Oct 2024 • Journal Article • Building and Environment
Quantifying the impact of vertical greenery systems (VGS) on Mediterranean urban microclimate during heat wave events
AbstractThis research investigates the potential of vertical greenery systems (VGS) to modulate the outdoor microclimate in a real-scale Mediterranean climate street canyon with respect to a non-vegetated control during four heat waves and summer conditions. The cooling effect of VGS on air temperature was assessed using an identical set of sensors in both canyons. The effect
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