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  1. 29 Aug 2023 Journal Article Cell Reports

    Dendritic cell ICAM-1 strengthens synapses with CD8 T cells but is not required for their early differentiation

    Anita Sapoznikov, Stav Kozlovski, Nehora Levi, Sara W Feigelson, Ofer Regev, Natalia Davidzohn, Shifra Ben-Dor, Rebecca Haffner-Krausz, Ester Feldmesser, Noa Wigoda, Ekaterina Petrovich-Kopitman, Moshe Biton, ... show all 13 authors
    Abstract

    Lymphocyte priming in lymph nodes (LNs) was postulated to depend on the formation of stable T cell receptor (TCR)-specific immune synapses (ISs) with antigen (Ag)-presenting dendritic cells (DCs). The high-affinity LFA-1 ligand ICAM-1 was implicated in different ISs studied in vitro. We dissect the in vivo roles of endogenous DC ICAM-1 in Ag-stimulated T cell proliferation

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  2. 24 Aug 2023 Journal Article Biomedicines

    Discriminative Identification of SARS-CoV-2 Variants Based on Mass-Spectrometry Analysis

    Liron Feldberg, Anat Zvi, Yfat Yahalom-Ronen, Ofir Schuster
    Abstract

    The spread of SARS-CoV-2 variants of concern (VOCs) is of great importance since genetic changes may increase transmissibility, disease severity and reduce vaccine effectiveness. Moreover, these changes may lead to failure of diagnostic measures. Therefore, variant-specific diagnostic methods are essential. To date, genetic sequencing is the gold-standard method to

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  3. 23 Aug 2023 Journal Article Archives of Toxicology

    “Catch-up" therapy: combining antidotal treatment with dermal application of AHA following percutaneous VX poisoning in the domestic swine

    Eugenia Bloch-Shilderman, Uri Nili, Victoria Nahum, Boris Smolkin, Nissan Ashkenazi
    Abstract

    Low-volatility organophosphorus chemical warfare agents (OP CWAs) are cholinesterase inhibitors which easily absorb into the skin, leading to the formation of a dermal depot from which they slowly enter the bloodstream. This leads to sustained cholinergic hyperstimulation, which if untreated may lead to death. However, current available countermeasures are not adequate

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  4. 20 Aug 2023 Journal Article International Journal of Molecular Sciences

    Phosphate Additives for Aging Inhibition of Impregnated Activated Carbon against Hazardous Gases

    Ido Nir, Vladislav Shepelev, Alexander Pevzner, Daniele Marciano, Lilach Rosh, Tal Amitay-Rosen, Hadar Rotter
    Abstract

    Impregnated activated carbons (IACs) used in air filtration gradually lose their efficacy for the chemisorption of noxious gases when exposed to humidity due to impregnated metal deactivation. In order to stabilize IACs against aging, and to prolong the filters’ shelf life, inorganic phosphate compounds (phosphoric acid and its three salts, NaHPO4, Na2HPO4, and Na3PO4)

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  5. 17 Aug 2023 Preprint Social Science Research Network

    Introducing Surface Roughness to a Stochastic and Rock’N’Roll Models to Describe Particle Resuspension in Turbulent Flows

    David Ben Shlomo, Roy Almog, Ziv Klausner, Eyal Fattal, Ronen Berkovich
    Abstract

    Resuspension phenomenon plays an important role in various environmental and industrial implications. Here we generalize a stochastic resuspension model (Fu et al., 2013) by incorporating a phenomenological adhesion model, which accounts for surface roughness (Rabinovich et al., 2000a) instead of its original interaction model that constructed to smooth surfaces to

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  6. 16 Aug 2023 Journal Article Molecules

    Enhanced LC-ESI-MS/MS Sensitivity by Cationic Derivatization of Organophosphorus Acids

    Tamar Shamai Yamin, Moran Madmon, Ariel Hindi, Avital Shifrovitch, Hagit Prihed, Merav Blanca, Avi Weissberg
    Abstract

    The chemical derivatization to enhance the signal intensity and signal-to-noise (S/N) of several organophosphorus (OP) acids in liquid chromatography tandem mass spectrometry (LC-ESI-MS/MS) is illustrated. The OP class of compounds represents the environmental degradants of OP nerve agents and pesticides. N-(2-(bromomethyl)benzyl)-N,N-diethylethanaminium bromide (CAX-B)

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  7. 10 Aug 2023 Journal Article Virus Research

    Characterization of a novel psyllid-transmitted waikavirus in carrots

    Ariel Shushan, Neta Luria, Oded Lachman, Noa Sela, Orly Laskar, Eduard Belausov, Elisheva Smith, Aviv Dombrovsky
    Abstract

    Carrots collected from the Western Negev region in Israel during the winter of 2019 showed disease symptoms of chlorosis, leaf curling, a loss of apical dominance, and multiple lateral roots that were not associated with known pathogens of the carrot yellows disease. Symptomatic carrots were studied for a possible involvement of plant viruses in disease manifestations

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  8. 13 Jul 2023 Journal Article Meteorologische Zeitschrift

    Is it foehn or sea breeze? Eulerian and Lagrangian analysis of the flow in the Jordan Valley

    Tobia Lezuo, Lukas Jansing, Dorita Rostkier-Edelstein, Michael Sprenger
    Abstract

    For more than one century, the penetration of the Mediterranean Sea Breeze into the Jordan Valley has been studied. At times, the associated downslope westerlies in the Dead Sea area exhibit foehn characteristics, leading to a warming and drying upon arrival and therefore contradicting the typical characteristics of a sea breeze. In this paper, a particular summer day

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  9. 29 Jun 2023 Journal Article Microorganisms

    Mind the Gap—A Perspective on Strategies for Protecting against Bacterial Infections during the Period from Infection to Eradication

    Yoav Gal, Hadar Marcus, Emanuelle Mamroud, Ronit Aloni-Grinstein
    Abstract

    The emergence of antibiotic-resistant bacteria is a pressing public health concern, highlighting the need for alternative approaches to control bacterial infections. Promising approaches include the development of therapeutic vaccines and the utilization of innate immune activation techniques, which may prove useful in conjunction with antibiotics, as well as other

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  10. 19 Jun 2023 Journal Article Sensors and Actuators B: Chemical

    Label-free and specific detection of active Botulinum neurotoxin in 0.5 μL drops with the meta-nano-channel field-effect biosensor

    Izhar Ron, Ie Mei Bhattacharyya, Soumadri Samanta, Vinay Shankar Tiwari, Doron Greental, Ruth Shima-Edelstein, Evgeny Pikhay, Yakov Roizin, Barak Akabayov, Gil Shalev
    Abstract

    Botulinum neurotoxins (BoNT) are the most poisonous and lethal substances known to humans, and as such there is a great need for fast, easy-to-use, and early BoNT detection technologies which are not available today. A biosensor based on field-effect transistor (FET) is a highly pursued sensing platform due to the inherent low-noise and amplification, low-cost, and the ultimate potential for the sensing of multiple

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