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  1. 2 Feb 2024 Journal Article Frontiers in Bioengineering and Biotechnology

    Enhanced production yields of rVSV-SARS-CoV-2 vaccine using Fibra-Cel® macrocarriers

    Noam Cohen, Irit Simon, Ophir Hazan, Arnon Tal, Hanan Tzadok, Lilach Levin, Meni Girshengorn, Lilach Cherry, Niva Natan, Tzadok Baruhi, Alon Ben David, Osnat Rosen, ... show all 37 authors
    Abstract

    The COVID-19 pandemic has led to high global demand for vaccines to safeguard public health. To that end, our institute has developed a recombinant viral vector vaccine utilizing a modified vesicular stomatitis virus (VSV) construct, wherein the G protein of VSV is replaced with the spike protein of SARS-CoV-2 (rVSV-ΔG-spike). Previous studies have demonstrated the

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  2. 16 Jan 2024 Journal Article Rapid Communications in Mass Spectrometry

    Ethanolysis of nitrogen mustards: A novel strategy for nitrogen mustard identification in environmental matrices by liquid chromatography–electrospray ionization–tandem mass spectrometry

    Chen Belay, Avital Shifrovitch, Hagit Prihed, Moran Madmon, Merav Blanca, Tamar Shamai Yamin, Avi Weissberg
    Abstract

    Rationale

    Nitrogen mustards (NMs) are blistering chemical warfare agents. The ability to detect NMs in environmental samples is very important for obtaining forensic evidence. The most common analytical techniques for NM detection are gas chromatography–mass spectrometry, which detects NMs in their intact form but is disadvantaged by high limits of detection (LODs)

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  3. 3 Jan 2024 Preprint bioRxiv

    Rapid and specific detection of single nanoparticles and viruses in microfluidic laminar flow via confocal fluorescence microscopy

    Paz Drori, Odelia Mouhadeb, Gabriel G Moya Muñoz, Yair Razvag, Ron Alcalay, Philipp Klocke, Thorben Cordes, Eran Zahavy, Eitan Lerner
    Abstract

    Mainstream virus detection relies on the specific amplification of nucleic acids via polymerase chain reaction, a process that is slow and requires extensive laboratory expertise and equipment. Other modalities, such as antigen-based tests, allow much faster virus detection but have reduced sensitivity. In this study, we report the development of a flow virometer for

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  4. Jan 2024 Journal Article International Journal of Climatology

    A multiscale approach to statistical downscaling of daily precipitation: Israel as a test case

    Dor Ziv Baruch Saaroni Sandler, Hadas Saaroni, Baruch Ziv, Assaf Hochman, Nili Harnik, Dorita Rostkier-Edelstein
    Abstract

    Rainfall in the Eastern Mediterranean is strongly modulated by complex topography and localized mesoscale processes. General circulation models (GCMs) struggle to capture daily precipitation variability in the region, both in time and in space. Rain in the Eastern Mediterranean occurs within a hierarchy of scales, as synoptic scale structures often drive local rainfall

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  5. Jan 2024 Book Chapter Curious Future Insight

    Medical Implications of Functional and Destructive Cellular Motions: Curiosity-Driven Open Issues

    Andre Rivalta, Disha-Gajanan Hiregange, Tanaya Bose, Gil Fridkin, K Shanmugha Rajan, Ada Yonath, Ella Zimmerman, Anat Bashan, Hagith Yonath
    Abstract

    Issues relating to the protoribosome, namely the origin of the universal machinery for genetic code translation, and structural flexibility of the current ribosomes, are analyzed and discussed in view of the creation of pathogen-specific antibiotics. In addition we are relating to ribosomopathies, namely diseases associated with genetic mutations of ribosomal components

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  6. Jan 2024 Journal Article Journal of Fluid Mechanics

    On local isotropy and scale dependence of pair dispersion in turbulent canopy flows

    Ron Shnapp, Alex Liberzon, Yardena Bohbot-Raviv, Eyal Fattal
    Abstract

    Canopy flows in the atmospheric surface layer play important economic and ecological roles, governing the dispersion of passive scalars in the environment. The interaction of high-velocity fluid and large-scale surface-mounted obstacles in canopy flows produces drag and causes intense, inhomogeneous and anisotropic turbulence. In this work, we focus on the turbulent

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  7. 1 Jan 2024 Journal Article Journal of Mass Spectrometry

    Software-assisted automated detection and identification of “unknown” fentanyl analogues

    Eyal Drug, Dana Marder, Iris Binyamin, Dina Yeffet, Eytan Gershonov, Shai Dagan
    Abstract

    Fentanyl and its non-pharmaceutical analogues (NPFs) are potent synthetic opioids, traditionally used for pain management, with ever-increasing illicit uses. Tightening the regulation for known fentanyls leads to new synthetic analogues in the opioid market. Furthermore, the Organization for the Prohibition of Chemical Weapons (OPCW) has recently issued a decision

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  8. 27 Dec 2023 Journal Article Plos One

    Essential role for Batf3-dependent dendritic cells in regulating CD8 T-cell response during SARS-CoV-2 infection

    Liat Bar-On, Hani Dekel, Moshe Aftalion, Theodor Chitlaru, Noam Erez
    Abstract

    SARS-CoV-2 infection elicits robust CD8 T-cell responses, yet the identity of the mechanisms playing dominant roles in initiating the virus-specific CD8 T-cell responses are largely unknown. In the present study, we interrogate the contribution of the cDC1 subset to SARS-CoV-2-specific CD8 T-cell immunity. For this purpose, we used a novel murine line which combines

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  9. 17 Dec 2023 Journal Article Environmental Science & Technology

    Urban Air-Quality Estimation Using Visual Cues and a Deep Convolutional Neural Network in Bengaluru (Bangalore), India

    Alon Feldman, Shai Kendler, Julian Marshall, Meenakshi Kushwaha, V Sreekanth, Adithi R Upadhya, Pratyush Agrawal, Barak Fishbain
    Abstract

    Mobile monitoring provides robust measurements of air pollution. However, resource constraints often limit the number of measurements so that assessments cannot be obtained in all locations of interest. In response, surrogate measurement methodologies, such as videos and images, have been suggested. Previous studies of air pollution and images have used static images

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  10. 7 Dec 2023 Preprint bioRxiv

    Doxycycline Levofloxacin or Moxifloxacin are superior to ciprofloxacin in treating anthrax meningitis in rabbits

    Amir Ben-Shmuel, Itai Glinert, Assa Sittner, Elad Bar-David, Josef Schlomovitz, Haim Levy, Shay Weiss
    Abstract

    Efficient treatment of anthrax related meningitis in patients poses a significant therapeutic challenge. Previously we demonstrated in our anthrax meningitis rabbit model that ciprofloxacin treatment in ineffective with most of the treated animals succumbing to the infection. Herein we tested the efficacy of Doxycycline in our rabbit model and found it highly effective

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