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  1. 3 Oct 2022 Journal Article Microbiology Spectrum

    Iron-Modified Blood Culture Media Allow for the Rapid Diagnosis and Isolation of the Slow-Growing Pathogen Francisella tularensis

    Efi Makdasi, Yafit Atiya-Nasagi, David Gur, Itai Glinert, Shlomo Shmaya, Elad Milrot, Theodor Chitlaru, Emanuelle Mamroud, Orly Laskar, Ofir Schuster
    Abstract

    The life-threatening disease tularemia is caused by Francisella tularensis, an intracellular Gram-negative bacterial pathogen. Due to the high mortality rates of the disease, as well as the low respiratory infectious dose, F. tularensis is categorized as a Tier 1 bioterror agent. The identification and isolation from clinical blood cultures of F. tularensis are complicated

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  2. 1 Oct 2022 Journal Article Experimental Eye Research

    Limbal stem cell deficiency (LSCD) in rats and mice following whole body exposure to sulfur mustard (SM) vapor

    Tamar Kadar, Vered Horwitz, Maayan Cohen, Inbal Egoz, Hila Gutman, Rellie Gez, Shlomit Dachir
    Abstract

    Ocular injuries following sulfur mustard (SM) exposure are characterized by an acute phase expressed by corneal erosions and inflammation of the anterior segment that after a clinically silent period may be followed by irreversible corneal injuries

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  3. 28 Sep 2022 Journal Article iScience

    Anti-SARS-CoV-2 immunoadhesin remains effective against Omicron and other emerging variants of concern

    Hadas Cohen-Dvashi, Jonathan J Weinstein, Michael Katz, Maayan Ashkenazy-Eilon, Yuval Mor, Amir Shimon, Hagit Achdout, Hadas Tamir, Tomer Israely, Romano Strobelt, Maya Shemesh, Liat Stoler-Barak, ... show all 16 authors
    Abstract

    Blocking the interaction of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with its angiotensin-converting enzyme 2 (ACE2) receptor was proved to be an effective therapeutic option. Various protein binders as well as monoclonal antibodies that effectively target the receptor-binding domain (RBD) of SARS-CoV-2 to prevent interaction with ACE2 were developed

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  4. 22 Sep 2022 Journal Article Vaccines

    A Novel Approach to Vaccine Development: Concomitant Pathogen Inactivation and Host Immune Stimulation by Peroxynitrite

    Shahar Rotem, Erez Bar-Haim, Uri Elia, Hila Cohen, Shirley Lazar, Ofer Cohen, Theodor Chitlaru, Yoav Gal
    Abstract

    The design of efficient vaccines for long-term protective immunity against pathogens represents an objective of utmost public health priority. In general, live attenuated vaccines are considered to be more effective than inactivated pathogens, yet potentially more reactogenic. Accordingly, inactivation protocols which do not compromise the pathogen’s ability to elicit

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  5. 20 Sep 2022 Journal Article Mathematics

    Is the Increased Transmissibility of SARS-CoV-2 Variants Driven by within or Outside-Host Processes?

    Yehuda Arav, Eyal Fattal, Ziv Klausner
    Abstract

    Understanding the factors that increase the transmissibility of the recently emerging variants of SARS-CoV-2 can aid in mitigating the COVID-19 pandemic. Enhanced transmissibility could result from genetic variations that improve how the virus operates within the host or its environmental survival. Variants with enhanced within-host behavior are either more contagious

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  6. 14 Sep 2022 Journal Article Vaccines

    Immunologic and Protective Properties of Subunit- vs. Whole Toxoid-Derived Anti-Botulinum Equine Antitoxin

    Alon Ben David, Ada Barnea, Amram Torgeman, Eran Diamant, Eyal Dor, Arieh Schwartz, Osnat Rosen, Noa Caspi, Miki Saraf, Elad Lerer, Yaakov Adar, Edith Lupu, ... show all 14 authors
    Abstract

    Botulism is a paralytic disease caused by botulinum neurotoxins (BoNTs). Equine antitoxin is currently the standard therapy for botulism in human. The preparation of equine antitoxin relies on the immunization of horses with botulinum toxoid, which suffers from low yield and safety limitations. The Hc fragment of BoNTs was suggested to be a potent antibotulinum subunit

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  7. 6 Sep 2022 Journal Article ChemistrySelect

    The Prominent Motif of the Leaving Group in Chemical and Biological Processes of Phosphonoesters: Understanding the Behavior of V-type Nerve Agents

    Shlomi Elias, Ishay Columbus, Ofir Shoshanim, Dana M Mizrahi, Ravit Chen, Lea Yehezkel, Lee Ghindes-Azaria, Nissan Ashkenazi, Yossi Zafrani
    Abstract

    The solvolysis of the extremely toxic nerve agent VX and its derivatives ((OEt)MeP(O)LG, LG is leaving group), promoted by nucleophiles such as fluoride, hydroxide/water or methoxide/methanol, revealed major differences in both reaction rates and products distribution. To rationalize these differences, which are of high relevance for different issues such as toxicity

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  8. 2 Sep 2022 Journal Article Toxins

    Characterization of Lung Injury following Abrin Pulmonary Intoxication in Mice: Comparison to Ricin Poisoning

    Anita Sapoznikov, Yoav Gal, Ron Alcalay, Yentl Evgy, Tamar Sabo, Chanoch Kronman, Reut Falach
    Abstract

    Abrin is a highly toxic protein obtained from the seeds of the rosary pea plant Abrus precatorius, and it is closely related to ricin in terms of its structure and chemical properties. Both toxins inhibit ribosomal function, halt protein synthesis and lead to cellular death. The major clinical manifestations following pulmonary exposure to these toxins consist of severe

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  9. Sep 2022 Conference Paper EMS Annual Meeting 2022

    Study of a unique fog event in Israel during January 2021: from measured microphysics, ground-remote sensing and satellite imagery to mesoscale forecasts and synoptic analysis

    Dorita Rostkier-Edelstein, Eyal Agassi, Pavel Kunin, Tamir Tzadok, Rong-Shyang Sheu, Adam Pitrkowski, Ayala Ronen
    Abstract

    This study describes a regional-scale fog event during 4 consecutive nights in January 2021, in Israel. During the event, we performed a first-of-its kind measurements campaign in Israel, with a variety of instruments, including both, in-situ measurements of droplets-size distribution, visibility range and meteorological parameters; and ground-based remote sensing with

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  10. 1 Sep 2022 Journal Article Eurosurveillance

    Monkeypox DNA levels correlate with virus infectivity in clinical samples, Israel, 2022

    Nir Paran, Yfat Yahalom-Ronen, Ohad Shifman, Shirley Lazar, Ronen Ben Ami, Michal Yakubovsky, Itzchak Levy, Anat Wieder Feinsod, Sharon Amit, Michal Katzir, Noga Carmi Oren, Ariela Levcovich, ... show all 28 authors
    Abstract

    The current monkeypox virus global spread and lack of data regarding clinical specimens’ infectivity call for examining virus infectivity, and whether this correlates with results from PCR, the available diagnostic tool. We show strong correlation between viral DNA amount in clinical specimens and virus infectivity toward BSC-1 cell line. Moreover, we define a PCR

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