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  1. 3 Aug 2022 Journal Article Industrial & Engineering Chemistry Research

    Nanostructured TiO2/MCM-41-Functionalized PDMS as a Reactive Protective Barrier against Chemical Warfare Agents via Adsorption and Catalyzed Degradation

    Hadar Rotter, Ruth Osovsky, Nir Hafif, Alexander Pevzner, Ido Nir
    Abstract

    Low permeability and self-decontamination are extremely desired features for protective equipment against chemical warfare agents (CWAs). ∼4 nm TiO2 nanoparticles were synthesized in the porous matrix of MCM-41 (45 wt%) as a novel reactive adsorbent for the degradation of sarin and VX. TiO2/MCM-41 (∼520 m2/g) was embedded in a polydimethylsiloxane (PDMS) sheet. PDMS

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  2. 3 Aug 2022 Journal Article Journal of the American Society for Mass Spectrometry

    Software-Assisted Automated Detection and Identification of “Unknown” Analogues: Implementation on V-Type Nerve Agents

    Eyal Drug, Eytan Gershonov, Nissan Ashkenazi, Yossi Zafrani, Ravit Chen, Shai Dagan
    Abstract

    V-type nerve agents are among the most toxic organophosphorus chemical warfare agents, and they are under strict regulation and supervision by the OPCW (Organization for the Prohibition of Chemical Weapons). The V-type class of materials refers to a potentially large number of analogues and isomers. In order to expose instances of unfulfillment of the OPCW treaty, it

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  3. 26 Jul 2022 Journal Article Viruses

    Matrix Metalloproteinases Expression Is Associated with SARS-CoV-2-Induced Lung Pathology and Extracellular-Matrix Remodeling in K18-hACE2 Mice

    Hila Gutman, Moshe Aftalion, Sharon Melamed, Boaz Politi, Reinat Nevo, Sapir Havusha-Laufer, Hagit Achdout, David Gur, Tomer Israely, Shlomit Dachir, Emanuelle Mamroud, Irit Sagi, ... show all 13 authors
    Abstract

    The COVID-19 pandemic caused by the SARS-CoV-2 infection induced lung inflammation characterized by cytokine storm and fulminant immune response of both resident and migrated immune cells, accelerating alveolar damage. In this work we identified members of the matrix metalloprotease (MMPs) family associated with lung extra-cellular matrix (ECM) destruction using

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  4. 19 Jul 2022 Journal Article Forensic Chemistry

    Dried urine spot and dried blood spot sample collection for rapid and sensitive monitoring of exposure to ricin and abrin by LC–MS/MS analysis of ricinine and l-abrine

    Lilach Yishai Aviram, Dan Loewenthal, Ariel Hindi, Sigalit Gura, Avi Weissberg, Shai Dagan
    Abstract

    Ricin and abrin are protein toxins found in plants. Their extreme toxicity raises concern for their use as bioterrorism agents. Extraction from castor bean seeds yields 1–5% ricin and 0.3–0.8% ricinine. Abrin and l-abrine were extracted from Arbrus precatorius beans in mass ratios of 0.12% and 0.45%, respectively. Hence, ricinine and l-abrine (which are small molecules)

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  5. 6 Jul 2022 Journal Article Tribology International

    Nanoscale contact mechanics of the interactions at monolayer MoS2 interfaces with Au and Si

    Liron Agmon, Roy Almog, Dana Gaspar, Guy Voscoboynik, Meenakshi Choudhary, Juergen Jopp, Ziv Klausner, Assaf Ya'akobovitz, Ronen Berkovich
    Abstract

    Molybdenum disulfide (MoS2) is a two-dimensional material that exhibits unique interfacial interactions with gold (Au) and silicon (Si). These interfaces have gained attention due to their potential to be integrated into a broad range of applications, where they involve direct contact that affects their performance. Here we investigate the nanoscale mechanical contact

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  6. 1 Jul 2022 Journal Article Forensic Chemistry

    Elucidation of synthetic N-benzyl cathinone structures using chemical derivatization and liquid chromatography–tandem mass spectrometry analysis

    Tamar Shamai Yamin, Avital Shifrovitch, Moran Madmon, Chen Belay, Hagit Prihed, Merav Blanca, Ariel Hindi, Yossi Zafrani, Anat Berliner, Avi Weissberg
    Abstract

    Synthetic cathinones are derivatives of cathinone, the psychoactive ingredient of the khat plant. These β-keto analogs of the corresponding α-methylphenethylamine (amphetamine) are one of the most popular categories of new psychoactive substances (NPSs), which have been widely associated with severe health problems and death by intoxication. One of the most common

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  7. 28 Jun 2022 Conference Paper EMS Annual Meeting 2022, Bonn, Germany, 5–9 Sep 2022

    A Factor Separation Study of the Effect of Synoptic‐Scale Wind, Atmospheric Moisture and of Their Synergy on the Diurnal Temperature Range During the Israeli Summer Using the WRF Single Column Model

    Dorita Rostkier-Edelstein, Maaian Rotstein, Pinhas Alpert
    Abstract

    The trend of the decrease in the global average diurnal temperature range (DTR) is one of the clearest signals in twentieth century climate data. Regionally, DTR trends exhibit large variations. A factor separation analysis was conducted to investigate the impact of atmospheric moisture, synoptic‐scale winds, and their synergy on the DTR during the Israeli summer. The

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  8. 28 Jun 2022 Journal Article Geophysical Research Letters

    Uncertainty in Projected Changes in Precipitation Minus Evaporation: Dominant Role of Dynamic Circulation Changes and Weak Role for Thermodynamic Changes

    Eilat Elbaum, Chaim I Garfinkel, Ori Adam, Efrat Morin, Dorita Rostkier-Edelstein, Uri Dayan
    Abstract

    End of century projections from Coupled Model Intercomparison Project (CMIP) models show a decrease in precipitation over subtropical oceans that often extends into surrounding land areas, but with substantial intermodel spread. Changes in precipitation are controlled by both thermodynamical and dynamical processes, though the importance of these processes for regional

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  9. 23 Jun 2022 Journal Article Journal of Medicinal Chemistry

    Studying Lipophilicity Trends of Phosphorus Compounds by 31P-NMR Spectroscopy: A Powerful Tool for the Design of P-Containing Drugs

    Ishay Columbus, Lee Ghindes-Azaria, Ravit Chen, Lea Yehezkel, Orit Redy-Keisar, Gil Fridkin, Dafna Amir, Daniele Marciano, Eyal Drug, Eytan Gershonov, Ziv Klausner, Sigal Saphier, ... show all 18 authors
    Abstract

    Systematically studying the lipophilicity of phosphorus compounds is of great importance for many chemical and biological fields and particularly for medicinal chemistry. Here, we report on the study of trends in the lipophilicity of a wide set of phosphorus compounds relevant to drug design including phosphates, thiophosphates, phosphonates, thiophosphonates

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  10. 14 Jun 2022 Journal Article Cell Reports

    Parsing the role of NSP1 in SARS-CoV-2 infection

    Tal Fisher, Avi Gluck, Krishna Narayanan, Makoto Kuroda, Aharon Nachshon, Jason C Hsu, Peter J Halfmann, Yfat Yahalom-Ronen, Hadas Tamir, Yaara Finkel, Michal Schwartz, Shay Weiss, ... show all 18 authors
    Abstract

    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to shutoff of protein synthesis, and nsp1, a central shutoff factor in coronaviruses, inhibits cellular mRNA translation. However, the diverse molecular mechanisms employed by nsp1 as well as its functional importance are unresolved. By overexpressing various nsp1 mutants and generating a SARS-CoV-2

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