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  1. May 2024 Journal Article Surfaces and Interfaces

    Introducing surface roughness in adhesion for stochastic and Rock'n'Roll models to describe particle resuspension in turbulent flows

    David Ben Shlomo, Roy Almog, Ziv Klausner, Eyal Fattal, Ronen Berkovich
    Abstract

    Resuspension of colloidal particles plays an important role in various environmental and industrial implications and is particularly influenced by the interactions at the particle-surface interface. Here we explore the effect of surface roughness on resuspension of colloidal particles by incorporating a phenomenological adhesion model that includes surface roughness

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  2. 1 May 2024 Journal Article Vaccines

    Induction of Superior Systemic and Mucosal Protective Immunity to SARS-CoV-2 by Nasal Administration of a VSV–ΔG–Spike Vaccine

    Yfat Yahalom-Ronen, Sharon Melamed, Boaz Politi, Noam Erez, Hadas Tamir, Liat Bar-On, Julia Ryvkin, Dena Leshkowitz, Ofir Israeli, Shay Weiss, Amir Ben-Shmuel, Moria Barlev-Gross, ... show all 16 authors
    Abstract

    The emergence of rapidly spreading variants of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) poses a major challenge to vaccines’ protective efficacy. Intramuscular (IM) vaccine administration induces short-lived immunity but does not prevent infection and transmission. New vaccination strategies are needed to extend the longevity of vaccine protection

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  3. 30 Apr 2024 Journal Article Antimicrobial Agents and Chemotherapy

    Doxycycline, levofloxacin, and moxifloxacin are superior to ciprofloxacin in treating anthrax meningitis in rabbits and NHP

    Amir Ben-Shmuel, Itai Glinert, Assa Sittner, Elad Bar-David, Josef Schlomovitz, Haim Levy, Shay Weiss
    Abstract

    Efficient treatment of anthrax-related meningitis in patients poses a significant therapeutic challenge. Previously, we demonstrated in our anthrax meningitis rabbit model that ciprofloxacin treatment is ineffective with most of the treated animals succumbing to the infection. Herein we tested the efficacy of doxycycline in our rabbit model and found it highly effective

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  4. 18 Apr 2024 Journal Article Frontiers in Pharmacology

    Effects of psilocybin, psychedelic mushroom extract and 5-hydroxytryptophan on brain immediate early gene expression: Interaction with serotonergic receptor …

    Elad Lerer, Alexander Botvinnik, Orr Shahar, Meitar Grad, Karin Blakolmer, Noam Shomron, Amit Lotan, Bernard Lerer, Tzuri Lifschytz
    Abstract

    Background: Immediate early genes (IEGs) are rapidly activated and initiate diverse cellular processes including neuroplasticity. We report the effect of psilocybin (PSIL), PSIL-containing psychedelic mushroom extract (PME) and 5-hydroxytryptophan (5-HTP) on expression of the IEGs, cfos, egr1, and egr2 in mouse somatosensory cortex (SSC). Methods: In our initial experiment

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  5. 16 Apr 2024 Journal Article nature communications

    Synergistic effect of two human-like monoclonal antibodies confers protection against orthopoxvirus infection

    Hadas Tamir, Tal Noy-Porat, Sharon Melamed, Lilach Cherry, Moria Barlev-Gross, Ron Alcalay, Yfat Yahalom-Ronen, Hagit Achdout, Boaz Politi, Noam Erez, Shay Weiss, Ronit Rosenfeld, ... show all 17 authors
    Abstract

    The eradication of smallpox was officially declared by the WHO in 1980, leading to discontinuation of the vaccination campaign against the virus. Consequently, immunity against smallpox and related orthopoxviruses like Monkeypox virus gradually declines, highlighting the need for efficient countermeasures not only for the prevention, but also for the treatment of already

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  6. 1 Apr 2024 Journal Article Vaccines

    Development and Validation of a Plaque Assay to Determine the Titer of a Recombinant Live-Attenuated Viral Vaccine for SARS-CoV-2

    Einat Toister, Lilach Cherry, Edith Lupu, Arik Monash, Eyal Dor, Lilach Levin, Meni Girshengorn, Niva Natan, Shira Chapman, Shlomo Shmaya, Eyal Epstein, Yaakov Adar, ... show all 15 authors
    Abstract

    The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in more than seven million deaths worldwide. To reduce viral spread, the Israel Institute for Biological Research (IIBR) developed and produced a new rVSV-SARS-CoV-2-S vaccine candidate (BriLife®) based on a platform of a genetically engineered vesicular stomatitis

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  7. 26 Mar 2024 Book Chapter Phage Engineering and Analysis: Methods and Protocols

    Contracting the Host Range of Bacteriophage T7 Using a Continuous Evolution System

    Tzvi Holtzman, Ram Nechooshtan, Ido Yosef, Udi Qimron
    Abstract

    Bacteriophage T7 is an intracellular virus that recognizes its host via tail and tail fiber proteins known as receptor-binding proteins (RBPs). The RBPs attach to a specific lipopolysaccharide (LPS) displayed on the host. While there are various reports of phage host range expansion resulting from mutations in the RBP encoding genes, there is little evidence for

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  8. 26 Mar 2024 Journal Article New Microbes and New Infections

    Insights from genomic analysis of a novel Coxiella burnetii strain isolated in Israel

    Inbar Cohen-Gihon, Ofir Israeli, Gal Bilinsky, Barak Vasker, Shirley Lazar, Adi Beth-Din, Anat Zvi, Nesrin Ghanem-Zoubi, Yafit Atiya-Nasagi
    Abstract

    The diagnosis of Q fever is challenging due to nonspecific symptoms and negative standard blood culture results. Serological testing through immunofluorescence assay (IFA) is the most commonly used method for diagnosing this disease. Polymerase chain reaction (PCR) tests can also be used to detect bacterial DNA if taken at an appropriate time. Once the presence of

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  9. 22 Mar 2024 Journal Article Analytical Methods

    Highly sensitive chemiluminescence sensors for the detection and differentiation of chemical warfare agents

    Orit Redy-Keisar, Alexander Pevzner, Gil Fridkin, Omri Shelef, Doron Shabat, Nissan Ashkenazi
    Abstract

    Highly sensitive chemiluminescence-based probes that effectively detect and differentiate between the extremely toxic real G- and V-type organophosphorus chemical warfare agents (OPCWAs) are presented. This straightforward approach does not require any instrumentation or light source; hence, it appears ideal for the future development of field colorimetric

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  10. Mar 2024 Journal Article Antibiotics

    Rapid Phenotypic Antibiotic Susceptibility Profiling of Clinical Escherichia coli and Klebsiella pneumoniae Blood Cultures

    Idan Hefetz, Rita Bardenstein, Shahar Rotem, Galia Zaide, Gal Bilinsky, Ohad Shifman, Oren Zimhony, Ronit Aloni-Grinstein
    Abstract

    Bloodstream infections (BSI) are defined by the presence of viable bacteria or fungi, accompanied by systemic signs of infection. Choosing empirical therapy based solely on patient risk factors and prior antibiotic susceptibility test (AST) may lead to either ineffective treatment or unnecessarily broad-spectrum antibiotic exposure. In general, Clinical & Laboratory

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