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2 Jul 2024 • Journal Article • Cell Death & Disease
Development of a local controlled release system for therapeutic proteins in the treatment of skeletal muscle injuries and diseases
AbstractThe present study aims to develop and characterize a controlled-release delivery system for protein therapeutics in skeletal muscle regeneration following an acute injury. The therapeutic protein, a membrane-GPI anchored protein called Cripto, was immobilized in an injectable hydrogel delivery vehicle for local administration and sustained release. The hydrogel was made
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Jul 2024 • Journal Article • Biomaterials Advances
Controlled release of vancomycin from PEGylated fibrinogen polyethylene glycol diacrylate hydrogel
AbstractSurgical site infection (SSI) is a common issue post-surgery which often prolongs hospitalization and can lead to serious complications such as sternal wound infection following cardiac surgery via median sternotomy. Controlled release of suitable antibiotics could allow maximizing drug efficacy and safety, and therefore achieving a desired therapeutic response. In this
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22 Jun 2024 • Preprint • arXiv
SHDB-AF: a Japanese Holter ECG database of atrial fibrillation
AbstractAtrial fibrillation (AF) is a common atrial arrhythmia that impairs quality of life and causes embolic stroke, heart failure and other complications. Recent advancements in machine learning (ML) and deep learning (DL) have shown potential for enhancing diagnostic accuracy. It is essential for DL models to be robust and generalizable across variations in ethnicity, age
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21 Jun 2024 • Journal Article • iScience
3D model of mouse embryonic pancreas and endocrine compartment using stem cell-derived mesoderm and pancreatic progenitors
AbstractThe developing mouse pancreas is surrounded by mesoderm compartments providing signals that induce pancreas formation. Most pancreatic organoid protocols lack this mesoderm niche and only partially capture the pancreatic cell repertoire. This work aims to generate pancreatic aggregates by differentiating mouse embryonic stem cells (mESCs) into mesoderm progenitors (MPs)
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7 Jun 2024 • Journal Article • Nature Communications
Depth-enhanced high-throughput microscopy by compact PSF engineering
AbstractHigh-throughput microscopy is vital for screening applications, where three-dimensional (3D) cellular models play a key role. However, due to defocus susceptibility, current 3D high-throughput microscopes require axial scanning, which lowers throughput and increases photobleaching and photodamage. Point spread function (PSF) engineering is an optical method that enables
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5 Jun 2024 • Journal Article • Reviews of Modern Physics
Fluorescence microscopy: A statistics-optics perspective
AbstractFundamental properties of light unavoidably impose features on images collected using fluorescence microscopes. Accounting for these features is often critical in quantitatively interpreting microscopy images, especially those gathering information at scales on par with or smaller than light’s emission wavelength. Here the optics responsible for generating fluorescent
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Jun 2024 • Journal Article • Nature Methods
DL4MicEverywhere: deep learning for microscopy made flexible, shareable and reproducible
AbstractDL4MicEverywhere is a platform that lets users train and implement their models in different computational environments. These environments include Google Colab, personal computational resources such as a desktop or laptop, and HPC systems. This flexibility is achieved by encapsulating each deep learning technique in an interactive Jupyter Notebook within a Docker
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Jun 2024 • Journal Article • Clinical Biomechanics
Elevated proinflammatory cytokines in response to mechanical stimulus are associated with reduced knee loading 2 years after anterior cruciate ligament reconstruction
AbstractBackground
The aim of this study was to test the hypothesis that proinflammatory cytokines correlate with knee loading mechanics during gait following a mechanical walking stimulus in subjects 2 years after anterior cruciate ligament reconstruction. Elevated systemic levels of proinflammatory cytokines can be sustained for years after injury. Considering roughly
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30 May 2024 • Journal Article • Rheumatology
Familial Mediterranean fever in patients with inflammatory bowel diseases: a nationwide study from the epi-IIRN
AbstractInflammatory bowel diseases (IBD) and familial Mediterranean fever (FMF) are auto-inflammatory diseases with common clinical and biological features. We aimed to determine their association and characterize the natural history in patients with both diagnoses.
Utilizing data from the epi-IIRN cohort, which includes 98% of Israel's population, we calculated the adjusted
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28 May 2024 • Journal Article • Biosensors and Bioelectronics
Robust, stretchable bioelectronic interfaces for cardiac pacing enabled by interfacial transfer of laser-induced graphene via water-response, nonswellable PVA gels
AbstractImplantable cardiac pacemakers are crucial therapeutic tools for managing various cardiac conditions. For effective pacing, electrodes should exhibit flexibility, deformability, biocompatibility, and high conductivity/capacitance. Laser-induced graphene (LIG) shows promise due to its exceptional electrical and electrochemical properties. However, the fragility of LIG
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