• 26 Oct 2021 Journal Article Advanced Functional Materials

    Recent Advances for Improving Functionality, Biocompatibility, and Longevity of Implantable Medical Devices and Deliverable Drug Delivery Systems


    The great majority of medical devices elicit foreign body response (FBR) postimplantation. FBR is a major hurdle to develop a successful device for impaired organs, leading to failure of devices/treatments. In recent times, several advantageous technologies have been developed based on either surface modifications or localized drug delivery systems (DDSs) in order to

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  • 19 Oct 2021 Journal Article Thinking Skills and Creativity

    Online vs. on-campus higher education: Exploring innovation in students' self-reports and students' learning products


    Innovation is an essential competency in the 21st century workplace, and hence, a required skill for higher education students. Studies on innovation in higher education examined the way students perceive themselves as innovators, while others examined the level of innovation in learning products. Research has yet to address the association between innovation as expressed

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  • 19 Oct 2021 Journal Article The Journal of Physical Chemistry C

    Uncovering the Change in Catalytic Activity during Electro-oxidation of Urea: Answering Overisolation of the Relaxation Phenomenon

    Bibhudatta Malik, Kalimuthu Vijaya Sankar, S K Tarik Aziz, Sumit Majumder, Yoed Tsur, Gilbert Daniel Nessim
    Electro-oxidation of urea offers tremendous opportunity for the economical hydrogen production option owing to its lower thermodynamic potential barriers. Slower reaction rate and multiple gas desorption steps hinder the implementation of urea-based fuel cells, and thus understanding the urea oxidation process is key for the commercialization of this technology. In this… show more
  • 15 Oct 2021 Journal Article Journal of Membrane Science

    A mixed-charge polyelectrolyte complex nanofiltration membrane: Preparation, performance and stability

    Michael Zelner, Philipp Jahn, Mathias Ulbricht, Viatcheslav Freger
    Ion selectivity of nanofiltration (NF) membranes is a critical factor in NF treatment of scaling-prone multi-ion effluents, such as wastewater. When removal of multivalent ions in such effluents is unnecessary or undesired, adjusting their rejection may mitigate scaling, in which case membranes combining oppositely charged electrolytes enable a tunable selectivity… show more
  • 14 Oct 2021 Journal Article Advanced Materials

    Stretchable and Highly Permeable Nanofibrous Sensors for Detecting Complex Human Body Motion

    Yehu David Horev, Arnab Maity, Youbin Zheng, Yana Milyutin, Muhammad Khatib, Miaomiao Yuan, Ran Yosef Suckeveriene, Ning Tang, Weiwei Wu, Hossam Haick

    Wearable strain sensors have been attracting special attention in the detection of human posture and activity, as well as for the assessment of physical rehabilitation and kinematics. However, it is a challenge to fabricate stretchable and comfortable-to-wear permeable strain sensors that can provide highly accurate and continuous motion recording while exerting minimal

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  • 1 Oct 2021 Journal Article Carbohydrate Polymers

    Insights into the formation mechanisms and properties of pectin hydrogel physically cross-linked with chitosan nanogels


    This study explores hydrogels based on the physical interaction between soluble pectin and chitosan nanogels. A simple technique for creating chitosan nanogels of controllable size was developed based on a two-step process: physical cross-linking with tripolyphosphate (TPP) and chemical cross-linking with genipin. The particles were stable at acidic pH, which allowed

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  • Oct 2021 Journal Article Journal of Power Sources Advances

    A surprising relation between operating temperature and stability of anion exchange membrane fuel cells

    Anion-exchange membrane fuel cells (AEMFCs) show substantially enhanced (initial) performance and efficiency with the increase of operational temperature (where typical values are below 80 °C). This is directly due to the increase in reaction and mass transfer rates with temperature. Common sense suggests however that the increase of ionomeric material chemical… show more
  • 28 Sep 2021 Journal Article Critical Reviews in Environmental Science and Technology

    A comprehensive review on water stable metal-organic frameworks for large-scale preparation and applications in water quality management based on surveys made since 2015

    Ruiying Li, Z S Wang, Z Y Yuan, Constance Van Horne, Viatcheslav Freger, M Lin, R K Cai, Jianlin P Chen

    Water is one of essential resources of modern society. Employing cost-effective technologies to treat water and wastewater is of vital importance for household uses, industries and the environment. Water-stable metal-organic frameworks (MOFs) have emerged as promising innovative materials for water treatment, due to their versatility and properties such as large internal

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  • 27 Sep 2021 Journal Article Advanced Materials

    Hybrid Organic–Inorganic–Organic Isoporous Membranes with Tunable Pore Sizes and Functionalities for Molecular Separation

    Zhenzhen Zhang, Assaf Simon, Clarissa Abetz, Martin Held, Anke-Lisa Höhme, Erik S Schneider, Tamar Segal-Peretz, Volker Abetz

    Accomplishing on-demand molecular separation with a high selectivity and good permeability is very desirable for pollutant removal and chemical and pharmaceutical processing. The major challenge for sub-10 nm filtration of particles and molecules is the fabrication of high-performance membranes with tunable pore size and designed functionality. Here, a versatile

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  • 26 Sep 2021 Preprint arXiv

    Cancer Progression as a Learning Process

    Drug resistance and metastasis - the major complications in cancer - both entail adaptation of cancer cells to stress, whether a drug or a lethal new environment. Intriguingly, these adaptive processes share similar features that cannot be explained by a pure Darwinian scheme, including dormancy, increased heterogeneity, and stress-induced plasticity. Here, we propose… show more
  • 21 Sep 2021 Journal Article Journal of Membrane Science

    High-performance radiation grafted anion-exchange membranes for fuel cell applications: Effects of irradiation conditions on ETFE-based membranes properties

    Ana Laura G Biancolli, Saja Haj-Bsoul, John C Douglin, Andrey S Barbosa, Rogério R de Sousa, Orlando Rodrigues, Alexandre J C Lanfredi, Dario R Dekel, Elisabete I Santiago

    Anion-exchange membrane fuel cells (AEMFCs) are rapidly gaining visibility in the clean energy research field due to their high power output and potential to significantly reduce materials costs. However, despite the high performances obtained, in-operando stability still presents a major obstacle for this technology. The durability issues are usually attributed to the

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  • 16 Sep 2021 Journal Article SPAST Abstracts

    Controlling Response of Polyaniline Towards Humidity by Self-Assembly Fatty Acids

    Weiwei Wu, Bin W ang, Yingying Jian, Jiang Xue, Tianqing Liu, Dingyi Yang, Yanping Liang, Huanran Feng, Ming-Shui Yao, Pengyi Xie, Ning Tang, Hossam Haick, Wenwen Hu
    Conductive polymers based sensors are potentially a powerful tool for detecting a variety of analytes in gas phase [1-2]. However, the accuracy and reliability of such sensors are threatened by the humidity interference, which limits their use in demanding applications of air-quality monitoring and healthcare [3]. Thus, there is an urgent need to suppress the response… show more
  • 16 Sep 2021 Journal Article Ceramics

    Influence of Isovalent ‘W’ Substitutions on the Structure and Electrical Properties of La2Mo2O9 Electrolyte for Intermediate-Temperature Solid Oxide Fuel Cells


    Lanthanum molybdenum oxide (La2Mo2O9, LAMOX)-based ion conductors have been used as potential electrolytes for solid oxide fuel cells. The parent compound La2Mo2O9 undergoes a structural phase transition from monoclinic (P21) to cubic (P213) at 580 °C, with an enhancement in oxide ion conductivity. The cubic phase is of interest because it is beneficial for oxide ion

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  • 15 Sep 2021 Journal Article Physical Review Fluids

    Bifurcation study for a surface-acoustic-wave-driven meniscus

    Kevin David Joachim Mitas, Ofer Manor, Uwe Thiele

    A thin-film model for a meniscus driven by Rayleigh surface acoustic waves (SAW) is analyzed, a problem closely related to the classical Landau-Levich or dragged-film problem where a plate is withdrawn at constant speed from a bath. We consider a mesoscopic hydrodynamic model for a partially wetting liquid, were wettability is incorporated via a Derjaguin (or disjoining)

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  • 14 Sep 2021 Preprint Research Square

    Putting Together the Puzzle of Ion Transfer in Single-Digit Carbon Nanotubes: Ab Initio Meets Mean-Field

    Nature employs channel proteins to selectively pass water across cell membranes, which inspires search for bio-mimetic analogues. Carbon nanotube porins (CNTPs) are intriguing mimics of water channels, yet ion transport in CNTPs still poses questions. As alternative to continuum models, here we present a molecular mean-field model, computing ab initio all required… show more
  • 12 Sep 2021 Journal Article Advanced Functional Materials

    Foliar Delivery of siRNA Particles for Treating Viral Infections in Agricultural Grapevines


    Grapevine leafroll disease (GLD) is a globally spreading viral infection that causes major economic losses by reducing crop yield, plant longevity, and berry quality, with no effective treatment. Grapevine leafroll associated virus-3 (GLRaV-3) is the most severe, prevalent GLD strain affecting wine production. Here, the ability of RNA interference (RNAi), a non-GMO

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  • 5 Sep 2021 Journal Article Nano-Micro Letters

    An Organic Solvent-Assisted Intercalation and Collection (OAIC) for Ti3C2Tx MXene with Controllable Sizes and Improved Yield

    Danyao Qu, Yingying Jian, Lihao Guo, Chen Su, Ning Tang, Xingmao Zhang, Wenwen Hu, Zheng Wang, Zhenhuan Zhao, Peng Zhong, Peipei Li, Tao Du, Hossam Haick, Weiwei Wu
    A good method of synthesizing Ti3C2Tx (MXene) is critical for ensuring its success in practical applications, e.g., electromagnetic interference shielding, electrochemical energy storage, catalysis, sensors, and biomedicine. The main concerns focus on the moderation of the approach, yield, and product quality. Herein, a modified approach, organic solvent-assisted intercalation… show more
  • 5 Sep 2021 Journal Article Progress in Polymer Science

    Polyamide desalination membranes: Formation, structure, and properties


    Empirical discovery, four decades ago, of polyamide membranes made by interfacial polymerization revolutionized large-scale desalination and has made desalinated water affordable to millions of people worldwide. The path to better understanding of the exceptional performance exhibited by these polymeric films, critical for rational membrane design and the search for

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  • 26 Aug 2021 Patent

    Volatile organic compounds as markers for cellular communication

    Hossam Haick, Yoav Y Broza, Mamatha Serasanambati, Dina Hashoul, Walaa Saliba
    The present invention provides methods of detecting cell-to-cell signaling in cancer cells and methods of diagnosing, prognosing and monitoring cancer comprising the use of volatile organic compounds, which are indicative of cell-to-cell signaling in cancer cells.
  • 24 Aug 2021 Journal Article Applied Catalysis B: Environmental

    Multi-scale study on bifunctional Co/Fe–N–C cathode catalyst layers with high active site density for the oxygen reduction reaction

    Weikang Zhu, Yabiao Pei, John C Douglin, Junfeng Zhang, Haoyang Zhao, Jiandang Xue, Qingfa Wang, Ran Li, Yanzhou Qin, Yan Yin, Dario R Dekel, Michael D Guiver
    Recently, much work has been devoted to designing catalysts with high porosity and efficient active sites. Although very promising results are achieved using Co/Fe–N–C catalysts based on rotating disk electrode (RDE) tests, actual fuel cell performance is below expectations, probably due to insufficient understanding of the catalyst layer (CL). Therefore, catalyst design… show more
  • 24 Aug 2021 Journal Article ACS Applied Materials & Interfaces

    Bifunctional Oxygen Electrocatalysis on Mixed Metal Phthalocyanine-Modified Carbon Nanotubes Prepared via Pyrolysis

    Yogesh Kumar, Elo Kibena-Põldsepp, Jekaterina Kozlova, Mihkel Rähn, Alexey Treshchalov, Arvo Kikas, Vambola Kisand, Jaan Aruväli, Aile Tamm, John C Douglin, Scott J Folkman, Ilario Gelmetti, Felipe A Garcés-Pineda, José Ramón Galán-Mascarós, Dario R Dekel, Kaido Tammeveski
    Non-precious-metal catalysts are promising alternatives for Pt-based cathode materials in low-temperature fuel cells, which is of great environmental importance. Here, we have investigated the bifunctional electrocatalytic activity toward the oxygen reduction reaction (ORR) and the oxygen evolution reaction (OER) of mixed metal (FeNi; FeMn; FeCo) phthalocyanine-modified… show more
  • 24 Aug 2021 Patent

    Hybrid muco-adhesive delivery systems and use thereof

    Havazelet Bianco-Peled, Avi Schroeder, Shlomit Avidan-Shlomovich, Yarden Degani, Mor Goldfeder
    A composition and method for the administration of therapeutic and/or diagnostic agents is provided. Specifically, a hybrid system, composed of polymer that harbors drug-loaded lipid nanoparticles, and use thereof for the administration of active agents e.g., anti-cancer agents, is provided.
  • 19 Aug 2021 Preprint arXiv

    Lamb-type solution and properties of unsteady Stokes equations

    In the present paper we derive the general solution of the unsteady Stokes equations in an unbounded fluid in spherical polar coordinates. The solution is an expansion in vector spherical harmonics and given as a sum of a particular solution, proportional to pressure gradient exhibiting power-law dependence, and a solution of vector Helmholtz equation decaying exponentially… show more
  • 15 Aug 2021 Journal Article Journal of Colloid and Interface Science

    Polymer dewetting in solvent-non-solvent environment- new insights on dynamics and lithography-free patterning

    Hypothesis We show that one may employ polymer dewetting in solvent-non-solvent environment to obtain lithography-free fabrication of well-defined nano- to micro- scale polymer droplets array from pre-patterned polymer films. The polymer droplet pattern may be converted to a series of hybrid organic-inorganic and inorganic well-defined nano-patterns by using sequential… show more
  • 12 Aug 2021 Journal Article Advanced Functional Materials

    Smart Materials Enabled with Artificial Intelligence for Healthcare Wearables

    Contemporary medicine suffers from many shortcomings in terms of successful disease diagnosis and treatment, both of which rely on detection capacity and timing. The lack of effective, reliable, and affordable detection and real-time monitoring limits the affordability of timely diagnosis and treatment. A new frontier that overcomes these challenges relies on smart… show more
  • 11 Aug 2021 Journal Article ACS Applied Materials & Interfaces

    Kinetic Resolution of Racemic Mixtures via Enantioselective Photocatalysis

    Despite the increasing demand for enantiopure drugs in the pharmaceutical industry, currently available chiral separation technologies are still lagging behind, whether due to throughput or to operability considerations. This paper presents a new kinetic resolution method, based on the specific adsorption of a target enantiomer onto a molecularly imprinted surface of… show more
  • 3 Aug 2021 Preprint arXiv

    Simplifying concentration-polarization of trace-ions in pressure-driven membrane processes

    Yoram Oren, Viatcheslav Freger, Oded Nir
    Accounting for concentration-polarization (CP) is critical for modeling solute transport in membrane separation processes. In a mixed-electrolyte solution, ions CP is affected not only by diffusion and advection but also by electromigration. Yet, the classic film model, lacking an electromigration term, is frequently used for modeling ion CP. Often, ion CP is altogether… show more
  • 1 Aug 2021 Journal Article Advanced Science

    Profiles of Volatile Biomarkers Detect Tuberculosis from Skin

    Rotem Vishinkin, Rami Busool, Elias Mansour, Falk Fish, Ali Esmail, Parveen Kumar, Alaa Gharaa, John C Cancilla, José S Torrecilla, Girts Skenders, Marcis Leja, Keertan Dheda, Sarman Singh, Hossam Haick

    Tuberculosis (TB) is an infectious disease that threatens >10 million people annually. Despite advances in TB diagnostics, patients continue to receive an insufficient diagnosis as TB symptoms are not specific. Many existing biodiagnostic tests are slow, have low clinical performance, and can be unsuitable for resource-limited settings. According to the World

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  • 1 Aug 2021 Journal Article Macromolecular Rapid Communications

    Ligand Valency Effects on the Alkaline Stability of Metallopolymer Anion-Exchange Membranes


    Long-term stability is a key requirement for anion-exchange membranes (AEMs) for alkaline fuel cells and electrolyzers that is yet to be fulfilled. Different cationic chemistries are being exploited to reach such a goal, and metallopolymers present the unique advantage of chemical stability towards strong nucleophiles as compared to organic cations. Yet, the few

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  • Aug 2021 Journal Article View

    Biointerfaced sensors for biodiagnostics

    Biointerfaced sensors have emerged as a new paradigm for medical applications that require an interface and/or intimate contact with biological components/systems such as cells, tissues, and whole organs. This article provides a review of the concept, design, and device characteristics of biointerfaced sensors needed for successful implementation of biodiagnostics and… show more
  • Aug 2021 Journal Article Progress in Organic Coatings

    The unique nanostructure of shellac films


    Shellac is a biocompatible resin of natural origin, comprising a mixture of polyesters and single esters, commonly used as a protective coating in the food and pharmaceutical industries. Remarkably, the physicochemical characteristics of shellac, in particular its excellent film forming, low vapor permeability, and good adhesion properties, are very untypical to low

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  • 29 Jul 2021 Journal Article Advanced Drug Delivery Reviews

    Advanced human-relevant in vitro pulmonary platforms for respiratory therapeutics

    Over the past years, advanced in vitro pulmonary platforms have witnessed exciting developments that are pushing beyond traditional preclinical cell culture methods. Here, we discuss ongoing efforts in bridging the gap between in vivo and in vitro interfaces and identify some of the bioengineering challenges that lie ahead in delivering new generations of human-relevant… show more
  • 29 Jul 2021 Journal Article Physical Review Fluids

    Biphasic co-flow through a sudden expansion or contraction of a Hele-Shaw channel

    Boris Rubinstein, Dana Zusmanovich, Zhenzhen Li, Alexander Leshansky

    In the present paper we study the biphasic co-flow through a Hele-Shaw cell with an abrupt change, either expansion or contraction, in channel width. Assuming gentle variation of the flow in the streamwise direction (valid at small capillary number), we derive the third-order nonlinear differential equation governing the shape of the interface separating the two fluids

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  • 26 Jul 2021 Journal Article Advanced Healthcare Materials

    Multifunctional Dressing for Wound Diagnosis and Rehabilitation


    A wound dressing is a sterile pad or compress that is used in direct contact with a wound to help it heal and prevent further issues or complications. Though wound healing is an intricate dynamic process that involves multiple biomolecular species, conventional wound dressings have a limited ability to provide timely information of abnormal conditions, missing the best

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  • 22 Jul 2021 Journal Article ACS Applied Materials & Interfaces

    Electrospun Ion-Conducting Composite Membrane with Buckling-Induced Anisotropic Through-Plane Conductivity

    Fuel cell (FC) is an attractive green alternative for today's fuel combustion systems. In common FCs, a polymer electrolyte membrane selectively conducts protons but blocks the passage of electrons and fuel. Nafion, the current benchmark membrane material, has a superior conductivity owing to unique morphology comprising randomly oriented elongated ionic nanochannels… show more
  • 9 Jul 2021 Book Chapter 2Nanofiltration: Principles, Applications, and New Materials, II, Second Edition

    Nanofiltration Membrane Characterization

    Anthony Szymczyk, Viatcheslav Freger

    The use of characterization techniques helps membrane scientists and engineers to follow a membrane throughout its life. Characterization tests can inspect membrane samples right after fabrication in order to check if a membrane batch meets expectations. Later, they become vital for rationalizing membrane separation performance and propensity to fouling and for gaining

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  • 1 Jun 2021 Journal Article The Journal of Physical Chemistry C

    Development of a Typical Distribution Function of Relaxation Times Model for Polymer Electrolyte Membrane Fuel Cells and Quantifying the Resistance to Proton Conduction within the Catalyst Layer

    Gal Avioz Cohen, Danny Gelman, Yoed Tsur
    In recent decades, polymer electrolyte membrane fuel cell (PEMFC) technologies have attracted research attention as promising candidates for next-generation energy conversion systems. This work deals with the effect of operating conditions and the construction of a typical model for PEMFCs, using electrochemical impedance spectroscopy (EIS) and distribution of relaxation… show more